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As the primary source of reducing equivalents, NADPH is primarily produced by glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase in the pentose phosphate pathway (PPP)

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Diana Aguiar de Sousa: No disclosures related with the specific topic, but has received personal fees from AstraZeneca, Organon, and Johnson & Johnson for advisory board participation, DSMB participation for the SECRET trial (University of British Columbia), and speaking fees from Astrazeneca and Bial