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In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation
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Recent research has suggested that GLP-1s could have a range of other benefits, including slowing aging in mice and holding back cognitive decline in people with Alzheimer’s disease
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