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[DOI] [PMC free article] [PubMed] [Google Scholar] Lucido MJ, Bekhbat M, Goldsmith DR, Treadway MT, Haroon E, Felger JC, Miller AH (2021) Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications

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High homocysteine links to many diseases and can affect: Glutathione production (your body's master antioxidant) Hormonal balance maintenance Mitochondrial protection Energy production capacity Anyone with methylation challenges should talk to a healthcare expert who understands methylation biochemistry before trying NAD+ supplements