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Several factors can reduce DAO levels or activity, including: Gut inflammation (due to infections, food intolerances, IBD, parasites) Leaky gut (increased intestinal permeability) Nutrient deficiencies (e.g., vitamin B6, vitamin C, copper, zinc) Medications (e.g., NSAIDs, antibiotics, antihistamines, antidepressants) Chronic stress Microbial imbalance (dysbiosis) Genetic polymorphisms affecting DAO gene expression Damage to the intestinal lining — where DAO is produced — is one of the most common contributors to low DAO activity and histamine intolerance
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Moreover, when the dismutation of superoxide anion takes place, it causes the formation of hydrogen peroxide, which is almost a weak free radical (104, 105)