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The majority of studies are conducted in rodent models, and while some findings are mechanistically interesting, animal data cannot be directly extrapolated to human safety or efficacy

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By using this setting, our study demonstrated a striking difference in the ability of B cells from RRMS patients to differentiate into both CD24 + CD38hi transitional-immature and CD24low/negCD38hi plasmablast-like B reg subsets, as compared to matched controls (Giacomini et al., 2017)