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Dietary adjustments often provide significant relief, including eating smaller, more frequent meals rather than large portions, avoiding high-fat or spicy foods that may exacerbate symptoms, and eating slowly to allow for better digestion

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As iron loading progresses, the capacity of transferrin to bind and detoxify iron is eventually exceeded, leading to non-transferrin-bound iron in plasma, which promotes oxidative stress, mitochondrial dysfunction, and ferroptosis (20)