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Enzymes such as cytochrome P450 (CYP), nitric oxide synthase (NOS), xanthine oxidase (XO), NADPH oxidase (NOX), cyclooxygenase (COX), and lipoxygenase (LOX) are central to the production of intracellular ROS [11,12] with NOX, composed of membrane-bound proteins gp91phox and p22phox, generating superoxide radicals by transferring electrons from NADPH to oxygen [13]

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