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KPV is a tripeptide derived from alpha-MSH that binds MC1R and MC3R receptors to suppress NF-kB signaling and reduce cytokine output in cell and animal studies

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Based on animal experiments , such therapeutic doses of pyridostigmine are able to increase the LD50 for soman by ~3-fold, which in theory should result in increase survival of soldiers exposed to soman (Newmark, 2004)