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However, various internal and external factors can disrupt this balanced distribution, causing melanin to accumulate in specific areas and creating the characteristic dark spots associated with hyperpigmentation

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J., Freyschmidt‐Paul P., Hoffmann R., et al., “Transfer of CD8(+) Cells Induces Localized Hair Loss Whereas CD4(+)/CD25(‐) Cells Promote Systemic Alopecia Areata and CD4(+)/CD25(+) Cells Blockade Disease Onset in the C3H/HeJ Mouse Model,” Journal of Investigative Dermatology 124, no