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Initially, the pathogenesis of NASH was explained by the “2-hit hypothesis”, where the first hit, hepatic triglyceride accumulation (steatosis), increases the liver’s susceptibility to injury from second hits, such as inflammatory cytokines, mitochondrial dysfunction, and oxidative stress [37,38]

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Research Evidence Comparison# CagriSema Research# The REDEFINE Phase 3 program provides robust evidence: REDEFINE 1 (3,417 participants, 20.4% weight loss at 68 weeks) and REDEFINE 2 (1,200 T2D participants, 13.7% weight loss)