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Its primary function is to transfer a methyl group to nicotinamide, a form of vitamin B3

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In a diabetes MRI substudy, liver fat fell up to 47% at 15 mg versus about 11% on insulin.⁶ In biopsy-confirmed fatty-liver disease with fibrosis, a large share of participants on 15 mg had disease resolution versus a small share on placebo.¹⁵ These are not microdose data