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The Act was amended to include a much higher standard: drugmakers now needed to conduct controlled trials in order to demonstrate that their products were effective

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"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: A randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial." The Lancet , 402(10404), 529-544