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Prophylactic Nrf2 activation by small molecules provide protection against a host of oxidative insults both in vitro as well as in vivo , including free radical donors and oxygen glucose deprivation (OGD), toxic levels of glutamate or N-methyl-D-aspartate (NMDA), neurotoxin or stroke-induced injury [16]

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alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population